tag:blogger.com,1999:blog-4724838399830873886.post6399485786164857821..comments2023-10-04T02:42:40.166-07:00Comments on Lucas Tafur: The darkside of leptinLucas Tafurhttp://www.blogger.com/profile/11675271094892394659noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-4724838399830873886.post-74669964739415263402011-07-28T04:58:07.363-07:002011-07-28T04:58:07.363-07:00Nice review post but I think you missed the bigges...Nice review post but I think you missed the biggest factor with leptin. It was never about how how high or low leptin levels are......it is about how leptin receptors can be rendered resistant by protein bending (proteomics) by phosphorylating kinases that render the organ systems unable to use it to control or dictate it's own cellular functions. This is precisely where the literature is taking the leptin story. I think looking at absolute leptin levels and effects is why amen bailed on it as a drug platform. I think you need to realize there is a lot more complexity to the story before you bury it. Dr. Kjohnhttp://www.blogger.com/profile/11126132841611727249noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-54308850119273897312011-07-28T07:24:40.721-07:002011-07-28T07:24:40.721-07:00In addition to "good" and "bad"...In addition to "good" and "bad" hormones, it's also common to push the idea of a "master" hormone/protein/etc.johnhttp://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-88735833335754309992011-07-28T07:29:09.283-07:002011-07-28T07:29:09.283-07:00john/Dr K,Lucas does acknowledge and cover your po...john/Dr K,<br><br>Lucas does acknowledge and cover your point.johnhttp://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-52609439000631532802011-07-28T12:16:05.464-07:002011-07-28T12:16:05.464-07:00Dr.K & john,I have the same opinion. I think w...Dr.K & john,<br><br>I have the same opinion. I think we can make a valid analogy with insulin. Having low insulin is good, but that doesnt means that insulin per se is bad, eventhough we know that high insulin is not desirable. Leptin is pro-inflammatory, so having chronic high levels of leptin is harmful. <br><br>Dysregulation of either SOCS3 and/or PTB1 can alter leptin normal signaling and metabolism contributing to leptin resistance and inflammation. But acute inflammation also increases leptin expression, which shows an active role during pathogenesis, in concert with other cytokines. Leptin and insulin are tighly coupled, and I think this is for a reason. The former is pro-inflammatory and the latter is anti-inflammatory and they both respond to a glucose load, which might represent physiological damage.Lucas Tafurhttp://www.blogger.com/profile/15688922609280098571noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-23494725121510227222011-07-29T18:53:35.471-07:002011-07-29T18:53:35.471-07:00Have to say, this blog is becoming, by far, the mo...Have to say, this blog is becoming, by far, the most scientifically informative and interesting out of the paleo/lowcarb/Taubes-inspired bunch... especially given that most of the others have prettymuch stopped posting (hyperlipid, panu) or gone in rather unproductive directions. So thanks for posting.Calhttp://whakahekeheke.tumblr.comnoreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-42248736512729223042011-07-30T06:55:43.294-07:002011-07-30T06:55:43.294-07:00Thanks for your words, Cal.Thanks for your words, Cal.Lucas Tafurhttp://www.blogger.com/profile/15688922609280098571noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-49847596051622612932011-07-31T17:21:58.302-07:002011-07-31T17:21:58.302-07:00Lucas, I'm glad to see someone with your crede...Lucas, I'm glad to see someone with your credentials blogging like this.<br><br>I followed a link to you from Jimmy Moore's site. <br><br>Please consider changing your design to dark print on a light background. Much easier to read for nearly everyone.Steve Parker, M.D.http://diabeticmediterraneandiet.comnoreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-27707481966830147822011-07-31T21:17:39.867-07:002011-07-31T21:17:39.867-07:00@Steve,Thank you. You are not the first to mention...@Steve,<br><br>Thank you. You are not the first to mention this issue, so Ive changed the look.Lucas Tafurhttp://www.blogger.com/profile/15688922609280098571noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-23693473734240164212011-08-02T14:14:04.505-07:002011-08-02T14:14:04.505-07:00Lucas, thank you for the dark type on a light back...Lucas, thank you for the dark type on a light background!<br><br>I've been posting links to your blog posts at Low Carb Friends, and hope to see more folks visiting and posting here.<br><br>I always enjoy reading your blog and thinking through my food plan, anew. Thank you for taking the time and effort to write.H.http://www.blogger.com/profile/08814810409621227506noreply@blogger.com