tag:blogger.com,1999:blog-4724838399830873886.post5151050394008233932..comments2023-10-04T02:42:40.166-07:00Comments on Lucas Tafur: BioenergeticsLucas Tafurhttp://www.blogger.com/profile/11675271094892394659noreply@blogger.comBlogger14125tag:blogger.com,1999:blog-4724838399830873886.post-76793597286993317012016-02-04T10:43:33.833-08:002016-02-04T10:43:33.833-08:00Thank you for this.Thank you for this.kellythttps://www.blogger.com/profile/15615287129718755631noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-30040544991925740852012-03-25T18:49:10.737-07:002012-03-25T18:49:10.737-07:00Lucas your work is fabulous.Lucas your work is fabulous.johnhttps://www.blogger.com/profile/11126132841611727249noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-7366001138541570192012-03-10T10:32:46.441-08:002012-03-10T10:32:46.441-08:00Thanks for the link! Veech's group has been wo...Thanks for the link! Veech's group has been working on that for a while and if the KE makes it, there should be no need to eat a very restricted ketogenic diet for achieving the benefits of ketosis. Lets see how it goes.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-90665920982666061512012-03-10T10:28:43.715-08:002012-03-10T10:28:43.715-08:00Peter (www.high-fat-nutrition.blogspot.com) had th...Peter (www.high-fat-nutrition.blogspot.com) had the following comment:<br /><br />Lucas, I have just spent several hours working through Veech's 1995 paper here in the early hours of the morning. I did a quick google to get a clearer idea of what, exactly, Eh7 was and landed on this post of yours as first clickable hit. I will pack up and go home now! Great post.<br /><br />BTW Liz fwded me this paper by Veech's group, getting a bit beyond physiological ketosis here, but interesting never the less. It's what sent me back to the 1995 paper:<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/22362892<br /><br />I have the full text, if you would like the pdf just email me.<br /><br />Dawn now, time to go feed the chickens!<br /><br />PeterAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-10641096184001098952012-02-29T14:34:18.731-08:002012-02-29T14:34:18.731-08:00The phenomena which make it difficult to build con...The phenomena which make it difficult to build conclusions on this, even after how thoroughly you present your case, is based on the fact that we, as homo sapiens, human, or whatever, have such meager knowledge when it comes to the big picture. Could be in 5-10 years that a new revelation is made and makes it very clear that ketosis is actually extremely stressful, you never know. The fact that the only really healthy population eating a keto diet are the inuit, and given the rather crazy selection of foods they eat I think it's extremely prudent to dip into ketosis on an intermittent basis.psychic24https://www.blogger.com/profile/02007506132069495095noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-28868896731439537312011-11-06T15:25:58.378-08:002011-11-06T15:25:58.378-08:00Acetyl CoA is also formed by beta-oxidation. Acety...Acetyl CoA is also formed by beta-oxidation. Acetyl CoA is formed by CoA (Coenzyme A) + an acetyl group. CoA synthesis is independent from glucose metabolism.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-77380627764222593942011-11-05T12:26:24.702-07:002011-11-05T12:26:24.702-07:00I mean the CoA itself that is cleaved off of pyruv...I mean the CoA itself that is cleaved off of pyruvate. I'm wondering if that CoA that is used to create acyl CoA is usually synthesized or is from glucose metabolism before the Krebs Cycle begins.Travis Culphttps://www.blogger.com/profile/02611059005476928227noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-77781602981707453832011-11-04T18:16:33.995-07:002011-11-04T18:16:33.995-07:00Travis,
The Krebs Cycle "starts" with t...Travis,<br /><br />The Krebs Cycle "starts" with the condensation of acetyl CoA and oxaloacetate. PDH catalyzes the formation of acetyl CoA from pyruvate. This step produces one more reduced NAD. <br /><br />Downstream from acetyl CoA, the metabolism of both fatty acids and glucose is nearly the same. The differences are between glycolysis and beta-oxidation.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-2415149384608756832011-11-04T13:13:19.523-07:002011-11-04T13:13:19.523-07:00Is the CoA usually synthesized or donated from pyr...Is the CoA usually synthesized or donated from pyruvate during the Krebs cycle? If the latter, would it make CHO/FA comparisons more complex?Travis Culphttps://www.blogger.com/profile/02611059005476928227noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-16965621665946674002011-05-09T15:33:34.561-07:002011-05-09T15:33:34.561-07:00Okay, that was a lot to try and go through--good w...Okay, that was a lot to try and go through--good work.<br><br>How does the greater ∆G of cytosolic ATP hydrolysis for ketones relate to uncoupling?<br><br>Do your conclusions revolve around the ideas of Nick Lane? How does the mitochondrial mutator mouse fit in?johnhttp://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-57563198168759143172011-05-11T14:19:17.724-07:002011-05-11T14:19:17.724-07:00Hello john,By making ketones out of excess acetyl ...Hello john,<br><br>By making ketones out of excess acetyl CoA, uncoupling produced by high FFA might be counterbalanced so most energy is not lost as heat. I havent read the work of Nick Lane deeply, but agree with most of what i have read.<br><br>Mutator mice seem to have lower ATP production and lower membrane potential by dysfunctional mitochondrial complexes, not related to increased ROS. From the data I have read, it seems that increased ROS production might increase mtDNA mutations, some which affect complex assembly and energy production, impairing mitochondrial and cell bioenergetics.Lucas Tafurhttp://www.blogger.com/profile/15688922609280098571noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-49235248844456738732011-05-13T21:28:55.027-07:002011-05-13T21:28:55.027-07:00Lucas I see your comment is gone. Anyway, are we ...Lucas I see your comment is gone. Anyway, are we sure that a metabolism that "wastes" energy as heat is a bad thing? Many long-lived animals generate high heat per unit (cell, gram of body weight) and have high uncoupling. I was under the impression that this was true on keto--is it more so on "optimal diet," being just out of keto? We would be getting max fat oxidation without high ketones; but, Peter has posted a paper showing ketones raise uncoupling ("Metabolism Nuts and Bolts"), and I think there is enough evidence that points towards them being beneficial, which is in agreement with you anyway.johnhttp://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-40618633193022341092011-05-14T13:40:50.958-07:002011-05-14T13:40:50.958-07:00Yes, blogger ate my comment. I dont see any proble...Yes, blogger ate my comment. I dont see any problem with energy dissipation as heat, it is required for the body homeostasis. The problem is when excess energy is dissipated as heat, ie. lack of ATP (think about mitochondrial uncouplers). I havent seen any direct evidence for ketones increasing UCP expression, only FFA.Lucas Tafurhttp://www.blogger.com/profile/15688922609280098571noreply@blogger.comtag:blogger.com,1999:blog-4724838399830873886.post-89725632093968230872011-05-14T14:54:11.018-07:002011-05-14T14:54:11.018-07:00"I havent seen any direct evidence for ketone..."I havent seen any direct evidence for ketones increasing UCP expression, only FFA."<br><br>My mistake, I found the same when I re-checked.johnhttp://www.blogger.com/profile/05161850700121191487noreply@blogger.com